Liquid Biopsy Technology To Advance Treatment For Prostate Cancer

Prostate cancer is the 2nd most widespread cancer in males and the 5th major reason for demise from cancer in males globally, as per the 2012 numbers. Although there are numerous feasible treatment alternatives for prostate cancer, several males that develop prostate cancer will not counter first-line therapies.

A research team from Leslie Dan Faculty of Pharmacy’s Department of Pharmaceutical Sciences, University of Toronto, has devised a new technique for liquid biopsy to recognize which patients might not counter standard therapy prior to it is administered. The facility to diagnose individuals using a blood sample rather than more invasive methods needed for traditional biopsies is also a revolution.

Shana Kelley, study’s lead investigator, clarified how her group has developed an entirely new advance using magnetic nanoparticles by means of DNA capture probes on their exterior that can aim CTCs (circulating tumor cells) in blood samples to make out if the cells include biomarkers linked to drug resistance.

Kelly said, “ten, we can ensnare the single magnetized cell in a microfluidic apparatus fabricated in the laboratory, separating them from the remaining cells in the specimen, and enabling us to execute extremely sensitive examination.” The cells with the utmost magnetic content would also contain a high expression of mRNA for the biomarker linked to drug resistance. This implies that individuals with high expression of mRNA should be accounted for other treatments as they will not counter the first-line therapy.”

Aiming CTCs, the one accountable for thinning out cancer, is significant as they hold data from the primary tumor that can enlighten therapy; but, they are outnumbered by normal cells by a billion-to-one in the blood of the patient and are thus, very difficult to isolate. As for subsequent measures, the result must be reproduced in a bigger research, Kelley explained. Also, the team is concentrating on “scaling up” and extending the use of this technique to other cancer forms and other diseases.

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